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    Verapamil potentially increases the concentration of phenytoin and phenytoin is predicted to decrease the exposure to verapamil. Severity of interaction: Severe
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    11/21/2014 · Phenytoin is an antiepileptic drug with several pharmacologic actions, including ion conductance, Na-K ATPase activity, synaptic transmission, and neurotransmitter release; the antiepileptic effects of phenytoin are thought to be primarily related to its action at the sodium channels during depolarization, preventing repetitive neuronal firing.
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    Phenytoin comes as an extended-release (long-acting) capsule, a chewable tablet, and a suspension (liquid) to take by mouth. The chewable tablet and suspension are usually taken two or …
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    Publications. Published: September 2011. Medicines interactions: the role of P-glycoprotein. Prescriber Update 32(3): 21-22 September 2011. P-glycoprotein is the most well known of the transmembrane efflux transporters and first surfaced in the 1970s as the reason for multidrug resistance in cancer cells.
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